Prevalence of hepatitis C virus (HCV) coinfection in HIV infected individuals in south India and characterization of HCV genotypes.
Indian J Med Microbiol
;
2009 Jan-Mar; 27(1): 12-6
Article
in English
| IMSEAR
| ID: sea-53559
ABSTRACT
PURPOSE:
To determine anti-HCV antibodies and genomic subtype of HCV in 1487 confirmed human immunodeficiency virus (HIV) positive samples.METHODS:
A total of 1487 confirmed HIV-positive samples were tested for anti-HCV antibodies by using a third generation ELISA kit (Ortho 3.0) and by RT PCR for HCV. HIV and HCV coinfected samples were selected for HCV genotyping by RFLP and subtyping with NS5-type specific primers.RESULTS:
A total of 1487 HIV-infected serum samples were screened for HCV infection, of which, a 1443 (97.04%) were negative and 45 (3.02%) were coinfected. HIV-HCV coinfection was predominant in the age group 41-50 years (51.1%). HCV genotyping and subtyping was done for the 45 HCV RNA-positive specimens of which genotype 1 was observed in 31 (68.8%) and genotype 3 was observed in 14 (31.1%) subjects. Further subtyping analysis showed the genotype 1b in 23 (51.1%), 1a in eight (17.7%), 3a in 10 (22.2%) and 3b in four (8.8%) subjects.CONCLUSION:
HIV and HCV seroprevalence is higher in South India, and the most prevalent genotype in coinfection was genotype 1b.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Polymorphism, Restriction Fragment Length
/
Female
/
Humans
/
Male
/
RNA, Viral
/
Enzyme-Linked Immunosorbent Assay
/
Comorbidity
/
HIV Infections
/
Prevalence
/
Age Factors
Type of study:
Prevalence study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Med Microbiol
Journal subject:
Microbiology
Year:
2009
Type:
Article
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