Serological evaluation of leptospirosis in Hyderabad Andhra Pradesh: a retrospective hospital-based study.
Indian J Med Microbiol
;
2007 Jan; 25(1): 24-7
Article
in English
| IMSEAR
| ID: sea-53812
ABSTRACT
PURPOSE:
Leptospirosis is a zoonotic disease with humans getting the infection either from rodent hosts or from domestic animals. Urine contaminated environment is the common source of infection. This is an under-reported disease in Andhra Pradesh. We report a retrospective hospital-based study on 55 patients with suspected leptospirosis.METHODS:
A total of 55 serum samples were collected from patients with suspected leptospirosis and subjected to serological testing by LeptoTek Dri-dot, microscopic agglutination test (MAT) and IgM enzyme-linked immunosorbent assay (ELISA). Identification of the predominant infecting serotype was done using a panel of 12 serovars.RESULTS:
MAT analysis of all the 55 samples identified all cases to be positive. The predominant serogroup was Icterohaemorrhagiae (68%) followed by Australis (22%), Autumnalis (8%) and Javanica (2%). LeptoTek Dri-dot showed a sensitivity of 96% as compared to MAT. IgM ELISA done on 32 samples showed a sensitivity of 86.7% compared to MAT.CONCLUSIONS:
MAT helped to identify Icterohemorrhagiae as the predominant serovar in this study. Despite the small number of samples analyzed, the data obtained establishes a need for a prospective study in this region.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Immunoglobulin M
/
Enzyme-Linked Immunosorbent Assay
/
Hemagglutination Tests
/
Serologic Tests
/
Cells, Cultured
/
Retrospective Studies
/
Hospitals
/
India
/
Leptospira
Type of study:
Diagnostic study
/
Observational study
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Med Microbiol
Journal subject:
Microbiology
Year:
2007
Type:
Article
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