An unusual seroconversion profile in a pregnant woman infected with the human immunodeficiency virus-1: need for using later generations HIV screening assays.
Indian J Med Microbiol
;
2008 Oct-Dec; 26(4): 390-2
Article
in English
| IMSEAR
| ID: sea-53881
ABSTRACT
The first HIV-1 marker that appears in blood following infection is HIV-1 RNA and usually the load is in millions of copies/ ml preceding seroconversion. A 24-year-old pregnant woman, gravida 2, parity 1 was tested for HIV as part of antenatal screening. Three samples were collected and tested from this individual over a period 70 days. The HIV-1 RNA level during seroconversion phase was very low, contrary to the well understood natural history of HIV infection. The reactivity rate in the ELISA and the Western Blot profile showed a gradual increase over the 70 days with a weak reactivity in a second generation assay (detects IgG only) for the third sample. This case illustrates the uncertainties regarding the serological window period in HIV infection and the need to use at least a third generation assay in testing centres for early detection of HIV infection.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pregnancy Complications, Infectious
/
Time Factors
/
Female
/
Humans
/
Pregnancy
/
RNA, Viral
/
Enzyme-Linked Immunosorbent Assay
/
AIDS Serodiagnosis
/
HIV Antibodies
/
HIV Infections
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Language:
English
Journal:
Indian J Med Microbiol
Journal subject:
Microbiology
Year:
2008
Type:
Article
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