Investigation of T cell receptors in the peripheral blood of patients with active pulmonary tuberculosis.
Indian J Med Microbiol
;
2009 Jan-Mar; 27(1): 40-3
Article
in English
| IMSEAR
| ID: sea-53930
ABSTRACT
T cells have the capability of recognizing target cells through their T cell receptors (TCRs). Thus, the percentages of CD3+/gamma-delta (gammadelta) TCR+ and CD3+/alpha-beta (alphabeta) TCR+ T lymphocytes were investigated in active and inactive pulmonary tuberculosis (PT) patients and in healthy individuals. CD3+ and CD3+/alphabeta TCR+ cell percentages were significantly lower in all PT patients than in healthy subjects. Percentages of CD3+/gammadelta and CD3+/alphabeta TCR+ were not statistically different between active and inactive PT patients. It was concluded that alphabeta TCR+ T cells might have a protective role in tuberculosis infection.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Tuberculosis, Pulmonary
/
Blood
/
Female
/
Humans
/
Male
/
Receptors, Antigen, T-Cell
/
T-Lymphocytes
/
T-Lymphocyte Subsets
/
CD3 Complex
/
Adult
Language:
English
Journal:
Indian J Med Microbiol
Journal subject:
Microbiology
Year:
2009
Type:
Article
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