Detection of extra-cellular enzymes of anaerobic gram-negative bacteria from clinically diseased and healthy sites.
Indian J Med Microbiol
;
2008 Jan-Mar; 26(1): 65-7
Article
in English
| IMSEAR
| ID: sea-54053
ABSTRACT
Anaerobic gram-negative bacteria (AGNB) produce enzymes that play a significant role in the development of disease. We tested 50 AGNB isolates, 25 each from clinically diseased and healthy human sites for in vitro production of caseinase, collagenase, etc. Majority of the isolates were Bacteroides fragilis and Porphyromonas gingivalis, which more commonly produced collagenase and haemolysin. Comparatively larger number of clinical AGNB produced collagenase (P = 0.004). No such difference was observed with other enzymes. Hence, collagenase is probably one of the key virulence markers of pathogenic AGNB, and the inhibitors targeting collagenases might help in the therapy of anaerobic infections.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Bacterial Proteins
/
Humans
/
Gram-Negative Bacterial Infections
/
Virulence Factors
/
Enzymes
/
Gram-Negative Anaerobic Bacteria
Type of study:
Diagnostic study
Language:
English
Journal:
Indian J Med Microbiol
Journal subject:
Microbiology
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS