Effect of T-cell depletion on bacterial multiplication and pattern of nerve damage in M. leprae-infected mice.
Indian J Lepr
;
1995 Oct-Dec; 67(4): 363-74
Article
in English
| IMSEAR
| ID: sea-54232
ABSTRACT
Various mechanisms for nerve damage in tuberculoid leprosy have been proposed. A common feature amongst them is the crucial role played by T-cells. Therefore, the present study was designed to determine the role of T-cells in the induction of nerve damage in leprosy using two different protocols for obtaining graded levels of T-cell depletion (i) Cyclosporine A, for depletion of T-helper cells and (ii) Anti Thy 1.2, for total depletion of T-cells. The findings indicate that the early changes seen in the unmyelinated fibres may not involve T-cells. However, the later stages of nerve damage associated with demyelination are dependent on T-cell responses.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Sciatic Nerve
/
Female
/
T-Lymphocytes
/
Demyelinating Diseases
/
Cyclosporine
/
Isoantibodies
/
Leprosy
/
Animals
/
Mice
/
Mycobacterium leprae
Language:
English
Journal:
Indian J Lepr
Journal subject:
Tropical Medicine
Year:
1995
Type:
Article
Similar
MEDLINE
...
LILACS
LIS