Mouse foot-pad studies with M. leprae--effect of desoxy fructo serotonin (DFS) and related compounds.
Indian J Lepr
;
1985 Apr-Jun; 57(2): 323-8
Article
in English
| IMSEAR
| ID: sea-54252
ABSTRACT
Mouse foot-pad experiments were carried out to study the effects of DFS and related compounds on the multiplication of M. leprae. Of the 25 cases clinically suspected Dapsone resistance, 8 were found resistant and 14 sensitive to Dapsone by mouse foot-pad experiments. Six were resistant to DFS and 16 were sensitive. Desoxy fructo 5-hydroxy tryptophane as well as Nutrition Antileprosy (NAL) diet were also found effective in suppressing the growth of M. leprae in mouse foot-pad. Of the two liposoluble derivatives of DFS tested (DFS LS-I and DFS LS-II), DFS LS-II was found more effective in suppressing the growth of M. leprae in foot-pads of mice.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Drug Resistance, Microbial
/
Serotonin
/
Dapsone
/
Foot
/
Leprostatic Agents
/
Leprosy
/
Animals
/
Mice
/
Mycobacterium leprae
Language:
English
Journal:
Indian J Lepr
Journal subject:
Tropical Medicine
Year:
1985
Type:
Article
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