Antigeneic cross-reactivity between ICRC-bacilli and M. leprae--"in vitro" evaluation.
Indian J Lepr
;
1984 Apr-Jun; 56(2): 219-31
Article
in English
| IMSEAR
| ID: sea-54495
ABSTRACT
Leucocyte migration inhibition, in presence of specific particulate antigen, is a good correlate of CMI. It can detect small differences in related antigens. In the present study, LMI was used to study the cross-reactivity between ICRC bacilli and M. leprae and also to examine the antigenic relationship amongst different ICRC isolates. The study showed a close antigenic cross-reactivity in lepromin and ICRC-in. LMI has brought out strain differences in two ICRC culture isolates, C-44 and C-75. The data appear to elucidate the possible strain specific antigenic relationship of M. leprae with its culture isolate e.g. ICRC strains. This may have important bearing on the development effective antileprosy vaccine for human use.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Spleen
/
Female
/
Cell Migration Inhibition
/
Bacterial Vaccines
/
BCG Vaccine
/
Cross Reactions
/
Lepromin
/
Leprosy
/
Leukocytes
/
Animals
Language:
English
Journal:
Indian J Lepr
Journal subject:
Tropical Medicine
Year:
1984
Type:
Article
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