In vitro and in vivo interactions of drugs used in multidrug therapy in leprosy.
Indian J Lepr
;
1991 Apr-Jun; 63(2): 166-79
Article
in English
| IMSEAR
| ID: sea-54510
ABSTRACT
Interactions of different drugs commonly used in multiple drug therapy were evaluated using both in vitro culture (cell-free as well as macrophage) system and mouse footpad. No additive effects were obtained in the in vitro system when dapsone was combined with either rifampicin or clofazimine, while a strong antagonism was observed when clofazimine was combined with rifampicin but not with rifabutin. In the mouse footpad system, a strong synergism was obtained when clofazimine was combined with either rifampicin or rifabutin, but significant antagonism was observed with the combination of clofazimine and dapsone.
Full text:
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Index:
IMSEAR (South-East Asia)
Main subject:
Rifampin
/
Rifamycins
/
Microbial Sensitivity Tests
/
Clofazimine
/
Rifabutin
/
Culture Media
/
Dapsone
/
Drug Interactions
/
Drug Therapy, Combination
/
Leprostatic Agents
Language:
English
Journal:
Indian J Lepr
Journal subject:
Tropical Medicine
Year:
1991
Type:
Article
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