Is PGL-1 also present in Leishmania donovani promastigotes?
Article
in English
| IMSEAR
| ID: sea-54586
ABSTRACT
A soluble antigen complex (SAC) derived from the ruptured promastigotes of Leishmania donovani parasites (LD-SAC) was used for complement fixation test (CFT) in leprosy Cases of tuberculoid and borderline tuberculoid leprosy, post-kala azar dermal leishmaniasis (TT, BT, PKDL) and control sera gave negative CFT. Smear-positive cases of borderline (BB, BL) and lepromatous (LL) leprosy and drug-resisting cases of pulmonary tuberculosis gave positive CFT; smear-negative cases of LL leprosy sera also gave positive CFT. Sera of smear-negative inactive LL patients contained only PGL-1 and PDIM antigens for a long time after they become inactive. Therefore, the positive CFT in inactive LL makes us suspect whether PGL-1 is present in LD promastigotes.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Leishmania donovani
/
Humans
/
Male
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Complement Fixation Tests
/
Glycolipids
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Leprosy, Borderline
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Leprosy, Lepromatous
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Leprosy, Tuberculoid
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Tuberculosis, Multidrug-Resistant
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Adult
Language:
English
Year:
1998
Type:
Article
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