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Experience with multidrug therapy in paucibacillary leprosy.
Indian J Lepr ; 1986 Apr-Jun; 58(2): 244-50
Article in English | IMSEAR | ID: sea-54650
ABSTRACT
Eighty paucibacillary leprosy cases were randomly put on two different multidrug regimens for 6 months followed by dapsone monotherapy. Regimen I was according to WHO (1982) recommendations consisting of Dapsone and six once a month rifampicin. In regimen II in addition to above two constituents, clofazimine was added 100 mg on alternate days. Dapsone thereafter was continued in both the regimens upto one year. The efficacy, acceptability and side effects of multidrug regimens were observed for a period of one year. Histopathological assessment was done on completion of multidrug therapy in all cases. A comparative evaluation of effect of two multidrug regimens in paucibacillary leprosy patients is reported. Addition of clofazimine over WHO (1982) recommended regimen appears to have no added benefit. The duration of WHO (1982) recommended regimens was found to be inadequate in many cases.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rifampin / Humans / Male / Clofazimine / Adult / Dapsone / Drug Therapy, Combination / Leprostatic Agents / Leprosy / Middle Aged Type of study: Controlled clinical trial / Practice guideline Language: English Journal: Indian J Lepr Journal subject: Tropical Medicine Year: 1986 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rifampin / Humans / Male / Clofazimine / Adult / Dapsone / Drug Therapy, Combination / Leprostatic Agents / Leprosy / Middle Aged Type of study: Controlled clinical trial / Practice guideline Language: English Journal: Indian J Lepr Journal subject: Tropical Medicine Year: 1986 Type: Article