Armadillo as a model for studying chemotherapy of leprosy: preliminary studies.
Indian J Lepr
;
1986 Jan-Mar; 58(1): 19-28
Article
in English
| IMSEAR
| ID: sea-54793
ABSTRACT
In order to determine the suitability of the armadillos as a model of human leprosy for chemotherapeutic studies, especially in evaluating newer anti-leprosy drugs, uninfected Armadillos were used to study the metabolic disposition of DDS. Serum DDS levels ranged from 500 ng/ml at 3 hours to 13 ng/ml at 96 hours after intravenous administration of DDS (1 mg/kg). In an ad libitum feeding trial of DDS it was found that the level of serum DDS varied according to the dose of DDS, and even at a dose of 0.0001%, the animals maintained MIC of DDS against M. leprae. Finally, it was demonstrated that armadillos acetylate DDS to MADDS and 7-9% of DDS is acetylated by armadillos.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Armadillos
/
Female
/
Male
/
Dapsone
/
Disease Models, Animal
/
Xenarthra
/
Leprosy
/
Animals
Language:
English
Journal:
Indian J Lepr
Journal subject:
Tropical Medicine
Year:
1986
Type:
Article
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