Bioavailability of dapsone on oral administration of Dapsomine--a comparative evaluation.
Indian J Lepr
;
1993 Apr-Jun; 65(2): 157-61
Article
in English
| IMSEAR
| ID: sea-55175
ABSTRACT
This study describes a comparative evaluation of dapsone kinetics in humans on administration of Dapsomine, a capsule containing dapsone 100 mg dispersed in oily-base suspension of clofazimine 50 mg. Seven untreated lepromatous leprosy patients were given one capsule of Dapsomine a day for seven days and the pharmacokinetics parameters in this group were compared with those from another group of seven patients who received dapsone 100 mg and clofazimine 50 mg separately. There were no statistically significant differences in parameters such as peak dapsone plasma concentration (Cmax), basal plasma level (C24h), time to peak level (tmax), absorption half-life (t1/2 alpha), elimination half-life t1/2 beta) and areas under plasma concentration-time curves (AUC0-8h) and AUC0-24h) between the two groups.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Drug Administration Schedule
/
Capsules
/
Biological Availability
/
Leprosy, Lepromatous
/
Chemistry, Pharmaceutical
/
Clofazimine
/
Dapsone
/
Drug Combinations
/
Half-Life
Language:
English
Journal:
Indian J Lepr
Journal subject:
Tropical Medicine
Year:
1993
Type:
Article
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