Conformational changes in the IgG molecule of lepromatous sera using laser Raman spectroscopy.
Indian J Lepr
;
1988 Jul; 60(3): 363-73
Article
in English
| IMSEAR
| ID: sea-55221
ABSTRACT
In the present work we report our studies on IgG separated from the serum of lepromatous patients and non-lepromatous leprosy cases using Laser Raman Spectroscopy. Striking spectral changes in LL cases have been observed in the following special regions (a) the amide I and III, (b) the S-S and C-S stretching (c) the skeletal bending and (d) skeletal stretching regions. These changes indicate a decrease in the amount of beta-structure and a transition towards alpha-helical conformation.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Protein Conformation
/
Mass Spectrometry
/
Stereoisomerism
/
Humans
/
Immunoglobulin G
/
Leprosy, Lepromatous
/
DNA-Binding Proteins
/
Lasers
Language:
English
Journal:
Indian J Lepr
Journal subject:
Tropical Medicine
Year:
1988
Type:
Article
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