Gelatin particle agglutination assay to detect anti-PGL-I antibodies in leprosy patients and in household contacts: a preliminary study.
Indian J Lepr
;
1992 Oct-Dec; 64(4): 461-7
Article
in English
| IMSEAR
| ID: sea-55246
ABSTRACT
A preliminary study of anti-phenolic glycolipid-I (PGL-I) IgM antibody detection using M. leprae gelatin particle agglutination (MLPA) test kit is described. Antibodies were demonstrated in 70% of our leprosy patients taking antileprosy treatment. The percentage of positivity of multibacillary cases was 86.0, whereas that of paucibacillary cases was 30.0. Good correlation was found between bacteriological index and the presence of antibodies. Antibodies were detected in 28% of our patients released from treatment. Fourteen out of 27 household contacts were found to have antibodies but none of the normal controls were seropositive. These preliminary data demonstrate that MLPA test is not applicable as sero-diagnostic test or as a test of cure, but may be useful for epidemiological studies and as a research tool.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Agglutination Tests
/
Glycolipids
/
Gelatin
/
Leprosy
/
Antibodies, Bacterial
/
Mycobacterium leprae
/
Antigens, Bacterial
Language:
English
Journal:
Indian J Lepr
Journal subject:
Tropical Medicine
Year:
1992
Type:
Article
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