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Generation and characterization of a human monoclonal antibody against phenolic glycolipid-I of M. leprae.
Indian J Lepr ; 1989 Oct; 61(4): 479-84
Article in English | IMSEAR | ID: sea-55341
ABSTRACT
The development of an Epstein-Barr virus transformed human B-cell line secreting a monoclonal antibody (MoAb), KR2/B5 is described. KR2/B5 is an IgM type of antibody and is highly specific for phenolic glycolipid-I (PGL-I) a component unique to M. leprae. The MoAb appears to be directed against the terminal sugar residue of the immunodominant trisaccharide component of PGL-I.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Humans / Glycolipids / Cell Transformation, Viral / Herpesvirus 4, Human / Leprosy / Antibodies, Monoclonal / Mycobacterium leprae / Antigens, Bacterial Language: English Journal: Indian J Lepr Journal subject: Tropical Medicine Year: 1989 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Humans / Glycolipids / Cell Transformation, Viral / Herpesvirus 4, Human / Leprosy / Antibodies, Monoclonal / Mycobacterium leprae / Antigens, Bacterial Language: English Journal: Indian J Lepr Journal subject: Tropical Medicine Year: 1989 Type: Article