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Effect of suppressor cells on antibody producing cells in mice infected with Mycobacterium leprae.
Indian J Lepr ; 1989 Jan; 61(1): 72-8
Article in English | IMSEAR | ID: sea-55378
ABSTRACT
Swiss albino mice were transfused with suppressor cells obtained after in vivo stimulation of mice with Con A (NS group). Some of the animals were infected with Mycobacterium leprae (NSI-group). Half of these animals were treated with dapsone (NSIT group). Adequate normal (NC) and infected (NI) controls were included. A plaque assay was carried out at different time periods to elucidate the effect of suppressor cells on antibody producing cells. No significant difference was seen in the number of plaque forming cells (PFC) in infected and dapsone treated animals (NSIT) when these were compared with controls. However significant increase seen in the number of IgM plaque forming cells at 6 months in NI and NSI groups and IgG PFC in NI group could be due to the peak footpad infection during this period. The significant decrease in the number of IgG PFC in NS and NSIT group compared to NC at 0 month is probably due to the suppressor cell activity in these groups.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Immunoglobulin G / Immunoglobulin M / Hemolytic Plaque Technique / T-Lymphocytes, Regulatory / Dapsone / Leprosy / Animals / Mice / Antibody-Producing Cells / Mycobacterium leprae Language: English Journal: Indian J Lepr Journal subject: Tropical Medicine Year: 1989 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Immunoglobulin G / Immunoglobulin M / Hemolytic Plaque Technique / T-Lymphocytes, Regulatory / Dapsone / Leprosy / Animals / Mice / Antibody-Producing Cells / Mycobacterium leprae Language: English Journal: Indian J Lepr Journal subject: Tropical Medicine Year: 1989 Type: Article