Ultrastructural study of epidermal Langherhans cells in leprosy.
Indian J Lepr
;
1984 Oct-Dec; 56(4): 840-3
Article
in English
| IMSEAR
| ID: sea-55401
ABSTRACT
ATPase staining and ultrastructural study of skin biopsies from six patients of leprosy (2TT, 4LL) and three normal subjects was carried out to study Langherhans Cells (LC). ATPase staining showed normal counts of LCs in tuberculoid patients, while significant reduction was observed in lepromatous cases. Electron microscopy revealed morphological changes in LL cases in the form of dense matrix and indistinct cristae of mitochondria; decreased number of lysosomes and rough endoplasmic reticulum; and numerous vacuoles in cytoplasm. TT cases showed normal morphology. Possible role of Langerhans Cells in pathogenesis of leprosy is discussed.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Skin
/
Humans
/
Microscopy, Electron
/
Langerhans Cells
/
Leprosy
Language:
English
Journal:
Indian J Lepr
Journal subject:
Tropical Medicine
Year:
1984
Type:
Article
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