Assessment of viability by normal mouse foot-pad and bacillary ATP bioluminescence assay in multibacillary cases treated with an MDT regimen using conventional as well as newer drugs like minocycline and ofloxacin.
Indian J Lepr
;
2000 Oct-Dec; 72(4): 437-42
Article
in English
| IMSEAR
| ID: sea-55473
ABSTRACT
The therapeutic effect of a drug regimen of conventional drugs as well as newer drugs like ofloxacin and minocycline in smear-positive multibacillary (MB) leprosy cases was assessed by mouse foot-pad and ATP bioluminiscence methods. Biopsies were taken before starting treatment and after one year of treatment. They were processed for viability assessment by normal mouse foot-pad inoculation and bacillary ATP assay techniques. The test regimen was quite effective in its anti-bacterial effect as it was found to result in loss of bacillary viability in all the cases, as assessed by both methods.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Adenosine Triphosphate
/
Treatment Outcome
/
Foot
/
Leprostatic Agents
/
Leprosy
/
Luminescent Measurements
/
Animals
/
Mice
/
Mycobacterium leprae
Language:
English
Journal:
Indian J Lepr
Journal subject:
Tropical Medicine
Year:
2000
Type:
Article
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