Blood dapsone levels in leprosy patients treated with acedapsone.
Indian J Lepr
;
1986 Jul-Sep; 58(3): 401-6
Article
in English
| IMSEAR
| ID: sea-55546
ABSTRACT
The metabolism of the repository drug acedapsone (DADDS,4,4'-diacetyldiaminodiphenyl sulfone) was studied in 15 individuals receiving 225 mg of DADDS, intramuscularly for a period of 75 days. Plasma levels of DDS were determined on the 2nd, 7th, 15th, 30th, 60th and 75th day after administration of the drug by spectrophoto-fluorometric technique. The mean peak levels of DDS (85.36 ng/ml) were noticed on 7th day followed by a gradual decrease in DDS concentration. The mean half-life level (44.53 ng/ml) of DDS were observed around the 15th day. The mean DDS level for the entire period of observation after one dose was 41.95 ng/ml. On the 75th day, the DDS level reached the minimum value of 14.76 ng/ml which was still about 5 times more than the minimal inhibitory concentration (MIC) level of DDS against M. leprae (3 ng/ml). The results are discussed.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Time Factors
/
Humans
/
Adult
/
Dapsone
/
Half-Life
/
Acedapsone
/
Leprosy
/
Animals
/
Mice
Language:
English
Journal:
Indian J Lepr
Journal subject:
Tropical Medicine
Year:
1986
Type:
Article
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