Neurobehavioral effects of low level fenvalerate exposure in mice.
Indian J Exp Biol
;
1997 Jun; 35(6): 623-7
Article
in English
| IMSEAR
| ID: sea-55636
ABSTRACT
Effect of oral administration of fenvalerate, a pyrethroid insecticide was studied in different behavioral paradigms in mice. Fenvalerate at 15, 30 and 45 mg/kg dose increased start latency, decreased ambulation and rearing in open-field, increased immobility in tail-suspension test and attenuated haloperidol-induced catalepsy in a dose-dependent manner. The time-course of data shows that these effects of fenvalerate may sustain up to several hours of its oral administration. The study indicates that pyrethroids can cause adverse behavioral effects even after a very low-level exposure. Although, it is difficult to extrapolate these findings directly to behavioral changes in man, they indicate that subtle behavioral dysfunction also occur in humans at exposures which do not cause acute toxicity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pyrethrins
/
Male
/
Catalepsy
/
Hindlimb Suspension
/
Dose-Response Relationship, Drug
/
Exploratory Behavior
/
Insecticides
/
Animals
/
Mice
/
Nitriles
Language:
English
Journal:
Indian J Exp Biol
Year:
1997
Type:
Article
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