Immunostimulatory effect of azadirachtin in Oreochromis mossambicus (Peters).
Indian J Exp Biol
;
2000 Nov; 38(11): 1092-6
Article
in English
| IMSEAR
| ID: sea-55651
ABSTRACT
The effect of azadirachtin, a triterpenoid derived from Azadirachta indica on the immune response was studied in the freshwater teleost, O. mossambicus. Bovine serum albumin (BSA) and sheep erythrocytes (SRBC) were used as antigens to evoke immune response. The immune responses in fish were measured by quantifying antibodies produced and counting the peripheral blood leucocytes in control and experimental fish. In general, azadirachtin significantly enhanced the antibody response and leucocyte count in a dose dependent manner. An inverse relationship was observed between the dose of azadirachtin and the degree of immunostimulation. Timing of azadirachtin administration in relation to immunization revealed that the maximum enhancement of antibody response was observed when the stimulant was given two days prior to immunization. The observed immunostimulatory property of azadirachtin has an implication in the maintenance of finfish health in freshwater intensive aquaculture practices.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Triterpenes
/
Female
/
Male
/
Adjuvants, Immunologic
/
Limonins
/
Fishes
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
2000
Type:
Article
Similar
MEDLINE
...
LILACS
LIS