Reduced nociceptive responses in mice with alloxan induced hyperglycemia after garlic (Allium sativum Linn.) treatment.
Indian J Exp Biol
;
1999 Jul; 37(7): 662-6
Article
in English
| IMSEAR
| ID: sea-55756
ABSTRACT
Administration of ethanol (95%) extract (45 mg/kg body wt/day for 28 days) of garlic (A. sativum) to alloxan induced diabetic (ALX-D) mice significantly lowered the serum glucose levels, nociceptive response in tail-flick, hotplate, allodynia, formalin test and relative thickness, weight of hind paw in formalin induced Paw oedema test, over 28 days, thus, showing the reversal trend in hyperglycemia and hyperalgesia compared to ALX-D mice. The reversal of hyperglycemia and hyperalgesia was progressive and more effective as duration of extract administration increased. The results suggest therapeutic potential of ethanol extract of garlic for anti-hyperglycemic and anti-nociceptive effects in diabetes.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pain
/
Plants, Medicinal
/
Male
/
Plant Extracts
/
Alloxan
/
Garlic
/
Hyperglycemia
/
Animals
/
Mice
Language:
English
Journal:
Indian J Exp Biol
Year:
1999
Type:
Article
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