Inhibition of rat brain nitric oxide synthase activity by cyclosporin-A.
Indian J Exp Biol
;
1996 Dec; 34(12): 1265-7
Article
in English
| IMSEAR
| ID: sea-55780
ABSTRACT
Cyclosporin-A, a potent immunosuppressive agent is known to induce cellular toxic side effects by way of altering calcium homeostasis, including calcium/calmodulin mediated events. We studied the in vitro and in vivo effects of cyclosporin-A on rat brain nitric oxide synthase activity (the enzyme that mediates the conversion of L-arginine to citrulline and NO). CsA in concentrations of 22-4400 nM inhibited rat brain NOS activity in vitro and in 10 or 25 mg/kg wt/4 weeks of CsA treated rat brains in vivo. We report here that CsA by way of interfering with rat brain Ca2+/CaM mediated events may inhibit its NOS activity which ultimately may result in neurotoxicity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Brain
/
Male
/
Cyclosporine
/
Rats, Sprague-Dawley
/
Nitric Oxide Synthase
/
Enzyme Inhibitors
/
Immunosuppressive Agents
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1996
Type:
Article
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