Influence of combined deficiency of fat and vitamin A on benzo(a)pyrene-induced lung carcinogenesis in rats.
Indian J Exp Biol
;
1994 Feb; 32(2): 124-7
Article
in English
| IMSEAR
| ID: sea-55798
ABSTRACT
The present study shows the effect of combined dietary deprivation of fat and vitamin A on benzo(a)pyrene (BaP) induced lung carcinogenesis in male Wistar rats. Lung tumors were induced by intratracheal instillation of BaP-Fe2O3 in normal saline. The tumor incidence and tumor burden in control animals were 82% and 2.28 respectively. Fat deficiency decreased the tumor incidence to 57% and tumor burden to 1.66. On the other hand, in vitamin A deficiency these were 83% and 4.02 respectively. Fat deprivation in the diet of animals fed with vitamin A deficient diet decreased the tumor incidence and tumor burden to 69.6% and 2.7 respectively. The results suggest a protective role of low intake of fat in vitamin A deficiency for BaP-induced lung tumorigenesis in rats.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Vitamin A Deficiency
/
Benzo(a)pyrene
/
Male
/
Dietary Fats
/
Rats, Wistar
/
Lung Neoplasms
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1994
Type:
Article
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