Genotoxic effects of poly-D-lysine in m-AMSA (amsacrine) treated Chinese hamster ovary (CHO) cells.
Indian J Exp Biol
;
1997 Jun; 35(6): 658-60
Article
in English
| IMSEAR
| ID: sea-55844
ABSTRACT
Cultured Chinese hamster ovary (CHO) cells were pre-treated with m-AMSA (amsacrine) and post-treated with different doses of polycationic compound poly-D-lysine (PDL) during G2 period in order to test on the frequency of chromatid-type aberrations. The present results indicate that PDL enhances the genotoxic action of m-AMSA measured as induced chromatid aberrations.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Polylysine
/
Amsacrine
/
Cricetinae
/
CHO Cells
/
DNA Topoisomerases, Type II
/
Enzyme Inhibitors
/
Animals
/
Mutagens
Language:
English
Journal:
Indian J Exp Biol
Year:
1997
Type:
Article
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