Ochratoxin induced hemolysis in rabbits.

ABSTRACT

A saline suspension of RBC when incubated with an increasing concentration (1 to 10 micrograms/ml) of crude ochratoxin at 37 degrees C for 16 hr showed a marked alteration in morphological characters followed by hemolysis. The effect was more pronounced with higher concentration of toxin. The result suggests extreme cytotoxic effect of ochratoxin on RBC leading to its lysis.