Studies on stibanate resistant Leishmania donovani isolates of Indian origin.
Indian J Exp Biol
;
2001 Mar; 39(3): 249-54
Article
in English
| IMSEAR
| ID: sea-55922
ABSTRACT
Studies with 26 clones of L. donovani promastigotes derived from three different Indian isolates indicated that wild type parasites are mixture of stibanate sensitive and resistant cells. Both forms of the parasite were resistant to the drug. Infection with resistant parasites appears to be the primary reason of high rate of pentavalent antimony unresponsiveness among Indian kala-azar patients. It was observed that the resistant parasites originated as a result of irregular and often incomplete treatment of kala-azar patients with pentavalent antimonials.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Leishmania donovani
/
Humans
/
Drug Resistance
/
Antimony Sodium Gluconate
/
India
/
Leishmaniasis, Visceral
/
Animals
/
Antiprotozoal Agents
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Exp Biol
Year:
2001
Type:
Article
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