Interrelationship of dietary lipids and ascorbic acid with hepatic enzymes of cholesterol metabolic pathway.
Indian J Exp Biol
;
1997 Jan; 35(1): 42-5
Article
in English
| IMSEAR
| ID: sea-56023
ABSTRACT
Effect of unsaturated and saturated fats on cholesterol metabolism was studied in ascorbate sufficient and deficient guineapigs. Experimental animals were made chronic ascorbic acid deficient by allowing oral intake of 0.5 mg ascorbic acid/day/animal. Elevation in serum and liver cholesterol and triglyceride along with depression in cholesterol oxidation and 7 alpha-hydroxylation in liver was observed in unsaturated fat fed guineapigs with ascorbate deficiency. Liver microsomal cytochrome P-450 level was found to be low in ascorbate deficient animals. Polyunsaturated fat intake could not lower the serum cholesterol level in ascorbate deficiency. Today polyunsaturated fat in the diet is encouraged all over the world for its hypocholesterolemic effect. This study indicates that polyunsaturated fat intake with ascorbic acid deficiency may produce hypercholesterolemia.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Ascorbic Acid
/
Triglycerides
/
Microsomes, Liver
/
Mitochondria, Liver
/
Dietary Fats
/
Cholesterol
/
Cytochrome P-450 Enzyme System
/
Guinea Pigs
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1997
Type:
Article
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