Evaluation of some newer non-steroidal anti-inflammatory indan-1-acids in various biological systems.
Indian J Exp Biol
;
1992 Jul; 30(7): 583-6
Article
in English
| IMSEAR
| ID: sea-56077
ABSTRACT
In line of the effort towards development of some newer indanyl non-steroidal anti-inflammatory agents and providing comprehensive SAR among this class of compounds some significantly active derivatives with low ulcerogenic potential were identified. Dealing with various long chain and branched chain compounds among this series, 3-(5, 6-dimethoxy indan-1-yl) propionic acid, 2-(5, 6-dimethoxy indan-1-yl) propionic acid and 3-(6-methoxy indan-1-yl) propionic acid were observed to have encouraging biological activity. Screening in various animal models of inflammation suggests their longer duration of action and lower ulcerogenic liability.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pain
/
Peptic Ulcer
/
Arthritis, Experimental
/
Rats
/
Body Temperature
/
Male
/
Anti-Inflammatory Agents, Non-Steroidal
/
Rats, Wistar
/
Dose-Response Relationship, Drug
/
Edema
Type of study:
Diagnostic study
/
Evaluation studies
Language:
English
Journal:
Indian J Exp Biol
Year:
1992
Type:
Article
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