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Antidiabetic, antihypercholesterolaemic and antioxidant effect of Ocimum sanctum (Linn) seed oil.
Indian J Exp Biol ; 2006 Apr; 44(4): 300-4
Article in English | IMSEAR | ID: sea-56178
ABSTRACT
Antihyperlipidaemic and antioxidant effect of Ocimum sanctum Linn. seed oil (OSSO) was investigated in rabbits. Administration of OSSO (0.8 g/kg body weight/day) for four weeks, in cholesterol (100 mg/kg body weight/day) fed rabbits significantly decreased serum cholesterol, triacylglycerol and LDL-+VLDL-cholesterol as compared to untreated cholesterol fed group. There was significant fall in atherogenic index in OSSO treated group. In addition, treatment with OSSO decreased lipid peroxidation and increased reduced glutathione content in blood. Antidiabetic effect of O. sanctum seed oil was evaluated in alloxan diabetic rabbits. Two weeks treatment of diabetic rabbits with OSSO (0.8 gm/kg/day) showed no significant hypoglycaemic effect. Results of the present study show that OSSO has hypocholesterolaemic and antioxidant effects but it does not have antidiabetic effect.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rabbits / Seeds / Blood Glucose / Plant Oils / Male / Plant Extracts / Thiobarbituric Acid Reactive Substances / Ocimum / Diabetes Mellitus / Lipid Metabolism Language: English Journal: Indian J Exp Biol Year: 2006 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rabbits / Seeds / Blood Glucose / Plant Oils / Male / Plant Extracts / Thiobarbituric Acid Reactive Substances / Ocimum / Diabetes Mellitus / Lipid Metabolism Language: English Journal: Indian J Exp Biol Year: 2006 Type: Article