Picroliv prevents oxidation in serum lipoprotein lipids of Mastomys coucha infected with Plasmodium berghei.
Indian J Exp Biol
;
1998 Apr; 36(4): 371-4
Article
in English
| IMSEAR
| ID: sea-56187
ABSTRACT
Picroliv, an iridoid glycoside mixture from the root and rhizome of Picrorhiza kurrooa, at the dose of 6 mg/kg p.o. for two weeks provided significant protection against the generation of lipid peroxidation products in serum beta-lipoproteins of P. berghei infected M. coucha. Incubation of normal rat hepatocytes with very low density lipoprotein or low density lipoprotein isolated from infected animals caused significant generation of lipid peroxides followed by a decrease in the viability of these cells, however these effects were partially reversed with the lipoproteins from infected and picroliv treated groups. High density lipoprotein from infected animals was not toxic to hepatocytes in vitro.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plasmodium berghei
/
Rats
/
Vanillic Acid
/
Plant Extracts
/
Lipid Peroxidation
/
Cells, Cultured
/
Cinnamates
/
Glycosides
/
Lipoproteins, HDL
/
Lipoproteins, LDL
Language:
English
Journal:
Indian J Exp Biol
Year:
1998
Type:
Article
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