In-vitro effect of estrogen-antagonist on motility and penetration ability of human spermatozoa.
Indian J Exp Biol
;
1997 Aug; 35(8): 822-4
Article
in English
| IMSEAR
| ID: sea-56207
ABSTRACT
Antiestrogens affect spermatozoa through their action on Leydig and Sertoli cells. Direct effect of antiestrogens namely tamoxifen and centchroman in concentration of 1, 2.5, 5, 10 and 20 micrograms/ml in incubation medium was determined on motility and penetration ability of human spermatozoa. Motility (%) was invariably reduced after 15, 30 and 60 min. of incubation. Addition of 17 beta-estradiol to medium with antagonist caused inhibition of motility in dose related manner. The distance travelled by spermatozoa treated with tamoxifen or centchroman in media was reduced by 30% and addition of estradiol along with antiestrogen reduced it to 50% compared to that of untreated spermatozoa.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Sperm Motility
/
Sperm-Ovum Interactions
/
Tamoxifen
/
Female
/
Humans
/
Male
/
Centchroman
/
Adult
/
Estradiol
/
Estrogen Antagonists
Language:
English
Journal:
Indian J Exp Biol
Year:
1997
Type:
Article
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