Increased apoptosis in AK-5 tumor cells after transfection with wild type p53 gene.
Indian J Exp Biol
;
1996 Oct; 34(10): 945-8
Article
in English
| IMSEAR
| ID: sea-56208
ABSTRACT
AK-5 tumor cell death is mediated through necrosis and apoptosis. The apoptotic activity in AK-5 cells has been studied after introduction of wild-type p53 gene. Apoptotic activity both in vitro and in vivo is significantly increased in p53 transfected cells. Similarly there is fragmentation of tumor cell DNA after undergoing apoptosis. These observations suggest an active participation of p53 in inducing apoptosis in AK-5 tumor cells.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Transfection
/
Genes, p53
/
Rats, Wistar
/
Apoptosis
/
Histiocytoma, Benign Fibrous
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1996
Type:
Article
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