Effect of monoamine antagonists on pretectal evoked analgesia in rat.
Indian J Exp Biol
;
1991 Jan; 29(1): 32-4
Article
in English
| IMSEAR
| ID: sea-56209
ABSTRACT
Mild and brief electrical stimulation of sites in the pretectal nucleus of rat produced analgesia (SPA) of long duration without significant aversion. Intracerebroventricular (icv) administration of 5-HT receptor antagonists methysergide (50 micrograms) and ketanserin (50 micrograms) and the dopaminergic antagonist haloperidol (50 micrograms) had no significant effect on pretectal SPA, but alpha and beta adrenoceptor antagonists phenoxybenzamine (50 micrograms) and sotalol (50 micrograms) on icv injection significantly antagonised the pretectal SPA. The results suggest that pretectal SPA involves activation of central adrenoceptors.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phenoxybenzamine
/
Rats
/
Serotonin Antagonists
/
Sotalol
/
Ketanserin
/
Biogenic Monoamines
/
Electric Stimulation
/
Haloperidol
/
Analgesia
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1991
Type:
Article
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