Protective effect of picroliv, active constituent of Picrorhiza kurrooa, against oxytetracycline induced hepatic damage.
Indian J Exp Biol
;
1997 Dec; 35(12): 1302-5
Article
in English
| IMSEAR
| ID: sea-56235
ABSTRACT
Picroliv, the active constituent of P. kurrooa, showed a dose dependent (1.5-12 mg/kg, po for 7 days) hepatoprotective activity against oxytetracycline induced hepatic damage in rat. It increased the number of viable hepatocytes (ex-vivo) significantly. Increase in bile volume and its contents in conscious rat suggests potent anticholestatic property. Picroliv also antagonised alterations in enzyme levels (GOT, GPT, and alkaline phosphatase) in isolated hepatocytes and serum, induced by oxytetracycline (200 mg/kg, i.p.) feeding. Picroliv was more potent than silymarin a known hepatoprotective drug.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Oxytetracycline
/
Rats
/
Silymarin
/
Vanillic Acid
/
Female
/
Male
/
Plant Extracts
/
Cinnamates
/
Glycosides
/
India
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Exp Biol
Year:
1997
Type:
Article
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