Neuroprotective effects of vitamin E in cold induced cerebral injury in guinea pigs.

Badhe, Prerna; Thorat, Jayant; Diyora, Batuk D; Mamidanna, Ravikrishna; Sayal, Parag; Badhe, Suvarna; Sharma, Alok K

Badhe, Prerna; Thorat, Jayant; Diyora, Batuk D; Mamidanna, Ravikrishna; Sayal, Parag; Badhe, Suvarna; Sharma, Alok K.

Indian J Exp Biol ; 2007 Feb; 45(2): 180-4

Article in English | IMSEAR | ID: sea-56371

ABSTRACT

ABSTRACT

Significant reduction in hemorrhage (10 v/s 13), necrosis (2 v/s 4), cavitations (7 v/s 13), neuronal degeneration, perivascular and parenchymal inflammatory infiltrate (7 v/s 11) were observed in Vitamin E treated cold induced head injury in guinea pigs, evaluated post injury using the modified Benderson's scale. The results suggest that Vitamin E is highly effective in promoting clinical and histopathological recovery in cold induced head injury in guinea pigs.

Subject(s)

Animals; Antioxidants/therapeutic use; Brain/pathology; Brain Injuries/drug therapy; Cold Temperature; Female; Guinea Pigs; Male; Neuroprotective Agents/therapeutic use; Random Allocation; Vitamin E/therapeutic use

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Vitamin E / Brain / Brain Injuries / Female / Male / Random Allocation / Cold Temperature / Neuroprotective Agents / Guinea Pigs / Animals Language: English Journal: Indian J Exp Biol Year: 2007 Type: Article

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