Psychopharmacological profile of hydro-alcoholic extract of Euphorbia neriifolia leaves in mice and rats.
Indian J Exp Biol
;
2005 Oct; 43(10): 859-62
Article
in English
| IMSEAR
| ID: sea-56441
ABSTRACT
The leaf extract of E. neriifolia significantly reduced apomorphine-induced stereotypy in mice at all doses (100, 200, 400 mg/kg body weight) in mice and rats and was devoid of catalepsic effect thereby, suggesting specific dopaminergic receptor modulating activity. The extract (400 mg/kg) potentiated pentobarbitone-induced hypnosis. It showed protection against maximal electro-shock-induced convulsion at 400 mg/kg. E. neriifolia leaf extract had anxiolytic action at 400 mg/kg by increasing the percentage of time spent in open arm in elevated plus-maze. The extract did not reverse scopolamine-induced amnesia on elevated plus-maze. It increased transfer latency at 200 and 400 mg/kg and also in combination with scopolamine. These results indicated anti-anxiety, anti-psychotic and anti-convulsant activity of E. neriifolia leaf extract in mice and rats. Phytochemical study showed the presence of steroidal saponin, reducing sugar, tannins, flavonoids in the crude leaf extract
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pentobarbital
/
Rats
/
Saponins
/
Time Factors
/
Antipsychotic Agents
/
Anti-Anxiety Agents
/
Body Weight
/
Carbohydrates
/
Plant Extracts
/
Dopamine Agents
Language:
English
Journal:
Indian J Exp Biol
Year:
2005
Type:
Article
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