Effect of chronic treatment with hydralazine on various in vitro preparations of rat.
Indian J Exp Biol
;
1996 Mar; 34(3): 205-7
Article
in English
| IMSEAR
| ID: sea-56463
ABSTRACT
Effect of chronic treatment with hydralazine (40 mg/kg/day) on isolated heart, anococcygeus muscle and myometrial preparations from rats has been studied. The treatment for 6 weeks caused a significant increase in isoprenaline induced positive inotropic response in rat heart. However, isoprenaline induced positive chronotropic effects were not altered significantly by chronic hydralazine treatment. Chronic hydralazine treatment also failed to alter noradrenaline induced contractile effects on rat anococcygeus muscle. However, on myometrial preparations from hydralazine treated rats showed an increase in adrenaline induced relaxations. The results of the present study can be explained on the basis of the effect of hydralazine on adenylate cyclase-cyclic adenosine monophosphate (cAMP).
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Time Factors
/
Female
/
Male
/
Rats, Wistar
/
Hydralazine
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1996
Type:
Article
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