Interrelation of xanthine oxidase and dehydrogenase and L-gulonolactone oxidase in animal tissues.
Indian J Exp Biol
;
1991 Jun; 29(6): 574-8
Article
in English
| IMSEAR
| ID: sea-56471
ABSTRACT
There is a correlation between phylogeny and the activities of L-gulonolactone oxidase (LGO), the key enzyme responsible for ascorbic acid (AH2) synthesis in animals and total xanthine oxidase and dehydrogenase [XOD(D/O)], the enzyme responsible for the production of endogenous superoxide radical (O2-.). LGO appears in the kidneys of amphibians and reptiles but livers of mammals. XOD(D/O) also is present mainly in the kidneys of amphibians and reptiles and livers of mammals. AH2 is a potential scavenger of O2-. and it appears that tissue specific expression of LGO takes place to counteract the endogenous O2-. toxicity. The interrelation of XOD(D/O) and LGO was also observed in the liver of rats during prenatal to postnatal development.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Anura
/
Oxygen
/
Reptiles
/
Sugar Alcohol Dehydrogenases
/
Xanthine Dehydrogenase
/
Xanthine Oxidase
/
L-Gulonolactone Oxidase
/
Liver
/
Animals
/
Mammals
Language:
English
Journal:
Indian J Exp Biol
Year:
1991
Type:
Article
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