Anti-cholestatic activity of HD-03, a herbal formulation in thioacetamide (TAA)-induced experimental cholestasis.
Indian J Exp Biol
;
1999 Apr; 37(4): 409-10
Article
in English
| IMSEAR
| ID: sea-56531
ABSTRACT
In the present study HD-03, a herbal formulation was investigated for its anti-cholestatic activity in TAA-induced cholestasis in anaesthetized guinea pigs. Administration of TAA at a dose of 100 mg/kg body wt significantly reduced the bile flow, bile acid and bile salt excretion. Pretreatment with HD-03 at a dose of 750 mg/kg body wt per orally for 15 days in guinea pigs significantly prevented thioacetamide-induced changes in bile flow, bile acids and bile salts excretion. Thus, HD-03 can serve as a potent choleretic and anti-cholestatic agent.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plants, Medicinal
/
Thioacetamide
/
Bile
/
Male
/
Cholagogues and Choleretics
/
Plant Extracts
/
Cholestasis
/
Guinea Pigs
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1999
Type:
Article
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