Effect of felodipine on cholinergic responses of the colonic smooth muscle of streptozotocin induced diabetic rats.
Indian J Exp Biol
;
1995 Apr; 33(4): 297-9
Article
in English
| IMSEAR
| ID: sea-56572
ABSTRACT
In streptozotocin induced diabetic rats, irrespective of felodipine treatment (5 mg/kg/day po for 4 weeks), a reduction in contractile response of colonic smooth muscle in vitro was observed. Similarly, in both control and diabetic rats treated with felodipine, contractile response was reduced. However, in felodipine treated diabetic rats there was a significant increase in response to exogenous acetylcholine. It may be of interest to study the effect of felodipine, on gastro-intestinal motility in vivo in diabetic rats, to enable extrapolation of the present results to the effect of felodipine on gastrointestinal complications of diabetes mellitus.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Female
/
Male
/
Acetylcholine
/
Felodipine
/
Rats, Wistar
/
Colon
/
Diabetes Mellitus, Experimental
/
Animals
/
Muscle, Smooth
Language:
English
Journal:
Indian J Exp Biol
Year:
1995
Type:
Article
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