Induction of tumour necrosis factor alpha in experimental animals treated with hepatotoxicants.
Indian J Exp Biol
;
1992 Aug; 30(8): 696-700
Article
in English
| IMSEAR
| ID: sea-56624
ABSTRACT
Administrations of hepatotoxicants namely carbon tetrachloride (CCl40.4 ml in 1.2 ml of liquid paraffin) and ANIT (1 ml of 1.5% solution in liquid paraffin) in Charles foster rats (force fed) and D-galactosamine (8 mg in water per swiss albino mouse, ip) induce the release of TNF-alpha in case of CCl4 and D-galactosamine. High TNF-alpha level was observed up to 48 hr in CCl4 and up to 24 hr in D-galactosamine treated animals. Elevated levels of biochemical like ALP and SGPT are also recorded. TNF-alpha level can be measured of tissue damage and prognosis in case of hepatitis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Carbon Tetrachloride
/
Tumor Necrosis Factor-alpha
/
Alanine Transaminase
/
Alkaline Phosphatase
/
Galactosamine
/
Liver
/
Animals
/
Mice
/
1-Naphthylisothiocyanate
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Exp Biol
Year:
1992
Type:
Article
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