Effects of stress on immune responsiveness, gastric ulcerogenesis and plasma corticosterone in rats: modulation by diazepam and naltrexone.

ABSTRACT

Effects of restraint stress (24 hr at room temperature) were evaluated on some immunological, visceral and endocrinal responses in rats. In animals sensitized with sheep RBC (SRBC), restraint stress (a) prevented the booster-induced rise in anti-SRBC antibody titre, (b) induced gastric mucosal erosions, and (c) elevated plasma corticosterone, when compared to non-stressed controls. Diazepam (1 or 10 mg/kg) consistently attenuated the effects of stress on all three parameters studied. The opioid antagonist, naltrexone (1 or 5 mg/kg) tended to aggravate these stress-induced effects. These concurrent biological changes during stress and their modulation by drugs are discussed in light of a possible correlation between endocrinal, immunological and visceral changes during such aversive stimuli.