Mechanism of spasmolytic activity of a fraction of Sarcostemma brevistigma Wight.
Indian J Exp Biol
;
2007 May; 45(5): 419-24
Article
in English
| IMSEAR
| ID: sea-56707
ABSTRACT
The effect of chloroform soluble fraction (F-A) of twigs of Sarcostemma brevistigma on contractions induced by KCl, histamine, and acetylcholine in the isolated guinea pig ileum and taenia coli smooth muscles has been evaluated. F-A (19.5 microg/ml) significantly inhibited the contraction induced by 40 mM KCl to the extent of 87.6% in the isolated guinea pig ileum. In the isolated guinea pig ileum, F-A (64.3 and 59.2 microg/ml) significantly inhibited the contractions induced by acetylcholine and histamine to the extent of 85 and 83% respectively. In the isolated guinea pig taenia coli, F-A (65.2 microg/ml) significantly inhibited the contraction induced by 40 mM KCl to the extent of 96.0%. The inhibitory effect of F-A (40 microg/ml) on the isolated guinea pig taenia coli was reduced by Bay K 8644 (10(-6) M) to the extent of 61.6 from 73.6%. These results suggest that the F-A may exhibit smooth muscle relaxant activity by blocking the Ca2+ channels.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Parasympatholytics
/
Potassium Chloride
/
Male
/
Plant Extracts
/
Verapamil
/
Acetylcholine
/
Histamine
/
Apocynaceae
/
Dose-Response Relationship, Drug
/
Guinea Pigs
Type of study:
Evaluation studies
Language:
English
Journal:
Indian J Exp Biol
Year:
2007
Type:
Article
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