Your browser doesn't support javascript.
loading
Mechanism of spasmolytic activity of a fraction of Sarcostemma brevistigma Wight.
Indian J Exp Biol ; 2007 May; 45(5): 419-24
Article in English | IMSEAR | ID: sea-56707
ABSTRACT
The effect of chloroform soluble fraction (F-A) of twigs of Sarcostemma brevistigma on contractions induced by KCl, histamine, and acetylcholine in the isolated guinea pig ileum and taenia coli smooth muscles has been evaluated. F-A (19.5 microg/ml) significantly inhibited the contraction induced by 40 mM KCl to the extent of 87.6% in the isolated guinea pig ileum. In the isolated guinea pig ileum, F-A (64.3 and 59.2 microg/ml) significantly inhibited the contractions induced by acetylcholine and histamine to the extent of 85 and 83% respectively. In the isolated guinea pig taenia coli, F-A (65.2 microg/ml) significantly inhibited the contraction induced by 40 mM KCl to the extent of 96.0%. The inhibitory effect of F-A (40 microg/ml) on the isolated guinea pig taenia coli was reduced by Bay K 8644 (10(-6) M) to the extent of 61.6 from 73.6%. These results suggest that the F-A may exhibit smooth muscle relaxant activity by blocking the Ca2+ channels.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Parasympatholytics / Potassium Chloride / Male / Plant Extracts / Verapamil / Acetylcholine / Histamine / Apocynaceae / Dose-Response Relationship, Drug / Guinea Pigs Type of study: Evaluation studies Language: English Journal: Indian J Exp Biol Year: 2007 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: IMSEAR (South-East Asia) Main subject: Parasympatholytics / Potassium Chloride / Male / Plant Extracts / Verapamil / Acetylcholine / Histamine / Apocynaceae / Dose-Response Relationship, Drug / Guinea Pigs Type of study: Evaluation studies Language: English Journal: Indian J Exp Biol Year: 2007 Type: Article