Effects of chronic systemic administration of opioid peptides, naloxone and N-acetyl beta-endorphin antiserum on gonadotropins and testicular functions in the rat.
Indian J Exp Biol
;
1998 Apr; 36(4): 361-6
Article
in English
| IMSEAR
| ID: sea-56726
ABSTRACT
Systemic administration of opioid peptides, methionine-enkephalin and beta-endorphin, chronically, lowered gonadotropin levels in plasma and had an inhibitory effect mainly on the testicular enzymes hyaluronidase, acid phosphatase and on incorporation of 3[H] thymidine in the tissue. When rats were similarly treated with opioid peptide antagonist naloxone and N-acetyl beta-endorphin antiserum, induced an opposite effect. This is either the direct effect of opioid peptides/antagonist on the gonads or it may be via the circulating levels of gonadotropin.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Testis
/
Male
/
Beta-Endorphin
/
Rats, Wistar
/
Opioid Peptides
/
Dose-Response Relationship, Drug
/
Animals
/
Naloxone
Language:
English
Journal:
Indian J Exp Biol
Year:
1998
Type:
Article
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