Superoxide dismutase, catalase and glutathione peroxidase activities in the brain of streptozotocin induced diabetic rats.
Indian J Exp Biol
;
1999 Feb; 37(2): 182-3
Article
in English
| IMSEAR
| ID: sea-56740
ABSTRACT
Brain antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) levels were studied in the brains of early diabetic (72 hr) and long term diabetic (one month) rats. Diabetes was induced by injecting streptozotocin (50 mg/kg, i.p.) in citrate buffer. One group of diabetic rats was treated with insulin (1U/day/animal). The results indicate that early diabetic rats exhibit increased SOD and CAT activities with no alteration in the GPX activity. On the contrary, increased CAT decreased GPX activities with no alteration in the SOD activity, was noted in the long-term Diabetic rats. Insulin treatment reversed these alterations in both the groups. It can be concluded that, in diabetic condition antioxidant enzyme levels are elevated and insulin treatment attenuated these changes. Hence, diabetes mellitus, if left untreated, may initiate degenerative processes and other CNS complications due to accumulation of oxidative free radicals.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Superoxide Dismutase
/
Brain
/
Catalase
/
Diabetes Mellitus, Experimental
/
Free Radicals
/
Glutathione Peroxidase
/
Animals
/
Antioxidants
Language:
English
Journal:
Indian J Exp Biol
Year:
1999
Type:
Article
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