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Evaluation of gastric anti-ulcer activity of fixed oil of Ocimum basilicum Linn. and its possible mechanism of action.
Indian J Exp Biol ; 1999 Mar; 37(3): 253-7
Article in English | IMSEAR | ID: sea-56754
ABSTRACT
Fixed oil of O. basilicum was found to possess significant antiulcer activity against aspirin, indomethacin, alcohol, histamine, reserpine, serotonin and stress-induced ulceration in experimental animal models. Significant inhibition was also observed in aspirin-induced gastric ulceration and secretion in pylorus ligated rats. The lipoxygenase inhibiting, histamine antagonistic and antisecretory effects of the oil could probably contribute towards antiulcer activity. O. basilicum fixed oil may be considered to be a drug of natural origin which possesses both antiinflammatory and anti-ulcer activity.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Stomach Ulcer / Plant Oils / Anti-Inflammatory Agents, Non-Steroidal / Rats, Wistar / Ocimum basilicum / Guinea Pigs / Animals / Anti-Ulcer Agents Language: English Journal: Indian J Exp Biol Year: 1999 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Stomach Ulcer / Plant Oils / Anti-Inflammatory Agents, Non-Steroidal / Rats, Wistar / Ocimum basilicum / Guinea Pigs / Animals / Anti-Ulcer Agents Language: English Journal: Indian J Exp Biol Year: 1999 Type: Article