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Depurination of ribosomal RNA and inhibition of viral RNA translation by an antiviral protein of Celosia cristata.
Indian J Exp Biol ; 2002 Oct; 40(10): 1195-7
Article in English | IMSEAR | ID: sea-56755
ABSTRACT
An antiviral protein (25 kD) isolated from leaves of Celosia cristata (CCP 25) was tested for depurination study on ribosomal RNA from yeast. Ribosomal RNA yielded 360 nucleotide base fragment after treatment with CCP 25 indicating that CCP 25 was a ribosome inactivating protein. CCP 25 also inhibited translation of brome mosaic virus (BMV) and pokeweed mosaic virus (PMV) RNAs in rabbit reticulocyte translation system. The radioactive assay showed that incorporation of [35S]-methionine was less in translation proteins of BMV nucleic acid when CCP 25 was added to translation system. This indicated that antiviral protein from Celosia cristata not only depurinated ribosomal RNA but also inhibited translation of viral RNA in vitro.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Antiviral Agents / Purines / Protein Biosynthesis / RNA, Ribosomal / RNA, Viral / Celosia / Mosaic Viruses Language: English Journal: Indian J Exp Biol Year: 2002 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Antiviral Agents / Purines / Protein Biosynthesis / RNA, Ribosomal / RNA, Viral / Celosia / Mosaic Viruses Language: English Journal: Indian J Exp Biol Year: 2002 Type: Article