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Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats.
Indian J Exp Biol ; 1999 Apr; 37(4): 340-3
Article in English | IMSEAR | ID: sea-56850
ABSTRACT
The activity of nimodipine and nitrendipine against pentylenetetrazole (PTZ) induced seizures in Albino rats was studied alone and in combination with valproate. The median effective dose [ED50] of valproate, nimodipine and nitrendipine were initially determined. All the 3 drugs were injected i.p. 30 min before the induction of seizures. Seizures were induced by PTZ 85 mg/kg i.p., and subsequently the effect of combining ED50 doses of nimodipine and nitrendipine with ED50 dose of valproate was evaluated. ED50 of valproate and nitrendipine were 129 and 2.5 mg/kg respectively. ED50 of nimodipine could not be established since a dose-response relationship was not obtained. Hence, for the purpose of combination studies, 4 mg/kg of nimodipine was used. Both nimodipine (4 mg/kg) and nitrendipine (2.5 mg/kg) decreased the ED50 of valproate from 129 to 40 mg/kg. Both nimodipine and nitrendipine potentiate the activity of valproate against PTZ induced seizures and can be considered as potential adjuvant anticonvulsants which merit further study.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pentylenetetrazole / Rats / Seizures / Female / Male / Nimodipine / Nitrendipine / Valproic Acid / Dose-Response Relationship, Drug / Drug Therapy, Combination Language: English Journal: Indian J Exp Biol Year: 1999 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pentylenetetrazole / Rats / Seizures / Female / Male / Nimodipine / Nitrendipine / Valproic Acid / Dose-Response Relationship, Drug / Drug Therapy, Combination Language: English Journal: Indian J Exp Biol Year: 1999 Type: Article